A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variantsArticle Published on 2022-10-062022-11-16 Journal: Cell Stem Cell [Category] COVID19(2023년), SARS, 변종, [키워드] cause Cell Cluster Dengue dengue virus disease-associated functional variant genome-wide association Genome-wide association study GWAS Human genetics identify indicated individuals Infection iPSC array isogenic hiPSC lines leakage of mtDNA locus Loss mitochondrial mtDNA NDUFA4 non-risk allele polymorphism provide risk risk allele SARS-CoV-2 SARS-COV-2 infection screening strategy sensitivity Signaling single-nucleotide single-nucleotide polymorphism SNP SNPs Stress susceptibility type I interferon type I interferon. upregulation viral infection viral infectivity virus Zika virus ZIKV [DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기
Functional associations between polymorphic regions of the human 3’IgH locus and COVID-19 disease인간 3'IgH 유전자좌의 다형성 영역과 COVID-19 질병 간의 기능적 연관성Article Published on 2022-09-052022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 변종, [키워드] age allele allelic Allelic polymorphisms Alpha association blood sample Blood samples Clinical outcome clinical outcomes Clinical severity collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients diffusion disease severity disequilibrium distribution DNA binding enhancer enhancer region ERα Estrogen Estrogen receptor alpha exhibited explain Genetic genetic background Genetic variant genetic variants genotyped SNP genotyped SNPs haplotypes heavy chain hospital hs1,2 enhancer. humans hypothese IgH locus immune response Immunoglobulin Infection Italy less linkage locus men MOST nine nucleotide Occurrence pandemic Pneumonia produced protective factor receptor Region SARS-COV-2 infection severe disease sex differences Sex-related differences significantly SNPs women [DOI] 10.1016/j.gene.2022.146698 PMC 바로가기 [Article Type] Article
Genome-wide association study of SARS-CoV-2 infection in Chinese population중국 인구의 SARS-CoV-2 감염에 대한 게놈 차원의 연관성 연구Article Published on 2022-09-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 변종, 진단, [키워드] analyzed ANKRD27 association Asymptomatic carried CD200R1L Chinese close contact conducted coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 severity ERAP1 Exome Genetic genetic association genetic variability Genetic variant genetic variants Genome sequencing Genome-wide association study global public health GWAS heterogeneous individual LINC00700 loci locus MAN1A2 molecular NEIL3 pathogenesis of COVID-19 Patient PCNX2 PLCL2 POLR2A Polymorphisms positive provided recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 Sequencing severity single-nucleotide Single-nucleotide polymorphisms suggested susceptibility Susceptibility. symptomatic patient tested therapeutic options ZMAT3 [DOI] 10.1007/s10096-022-04478-5 PMC 바로가기 [Article Type] Article
A Multitrait Locus Regulates Sarbecovirus PathogenesisArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analysis approach CCR9 chromosome 9 collaborative cross conserved coronavirus coronavirus disease Coronavirus infection cross CXCR6 disease facilitate Follow-up Genes Genetic genetic determinant genetic mapping Genetic variation GWAS help highly pathogenic Host host response host susceptibility humans identify implementation Infection Infectious disease influence loci locus mice Mortality mouse model outcome outcomes Pathogenesis pathogenic Precision predict Protective regulate sarbecovirus Sarbecoviruses sarbecoviruses. SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 infections severe disease severity strain susceptibility susceptibility allele variety Viral diseases Virus Disease [DOI] 10.1128/mbio.01454-22 PMC 바로가기
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis Research Published on 2022-08-302022-10-05 Journal: Nature Communications [Category] 변종, [키워드] acquisition Analysis analysis antibiotic average Bayesian changes in clade compensatory mutation complex distributions drug drugs Epidemic Eurasia Evolution Factor Genetic Genome sequencing isolate Lineage locus MDR MDR-TB Mortality Mutation Mycobacterium tuberculosis Prevalence regimens responsible Spread strain Strains Tolerance Transmission Tuberculosis widespread [DOI] 10.1038/s41467-022-32455-1 [Article Type] Research
Host genomics of SARS-CoV-2 infectionSARS-CoV-2 감염의 숙주 유전체학Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute infection approach approaches association Asymptomatic causal variant complications COVID-19 COVID-19 pneumonia demographic disease disease severity downstream Exome explain exploration Factor fraction functional genetic determinant genetic determinants Genetic variant Genome sequencing Genome-wide association studies genomic study highlighting host-virus interactions Human human genetic variation immune function individuals International involved life-threatening locus management Mild outcome pandemic Pathogenesis pathway Pathways Pneumonia Region required SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 pathogenesis severe cases shown therapeutic targets type I interferon type I interferon response Variability with COVID-19 [DOI] 10.1038/s41431-022-01136-4 PMC 바로가기 [Article Type] Review
Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer’s Disease (NorAD): study protocol for a randomised clinical trial and COVID-19 amendments알츠하이머병(NorAD)에서 연장 방출 구안파신을 사용한 노르아드레날린성 추가 요법: 무작위 임상 시험 및 COVID-19 수정안에 대한 연구 프로토콜Article Published on 2022-08-012022-09-11 Journal: Trials [Category] 임상, [키워드] activities activity Add-on therapy addition Adrenergic receptor affected Alzheimer's disease Alzheimer’s disease approved assessment Attention attention deficit baseline Brain burden cholinesterase inhibitor clinical trial Cognition cognitive Combination combination therapy COVID-19 Daily daily living determine disease disorder double-blind dysfunction evaluate Evidence executive Follow-up function Guanfacine Guanfacine. hyperactivity IMPROVE include interview inventory involved locus measure Mild mild to moderate moderate modulating Neuropsychiatric NorAD noradrenergic observation outcome participant pathological change pathological changes pathway Pathways Placebo placebo group placebo-controlled Primary outcome randomised receive receptor Regulation secondary Secondary outcomes Study protocol Symptom symptomatic synergistic synergistic effect Test the placebo group thought Treatment treatment group Trial [DOI] 10.1186/s13063-022-06190-3 PMC 바로가기 [Article Type] Article
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestriesOAS1 넌센스 매개 부패의 유전적 조절은 유럽 및 아프리카 혈통의 환자에서 COVID-19 입원과의 연관성을 뒷받침합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료법, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African allele Analysis analysis Antiviral association Bioinformatic clearance clinical trial contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity decrease disease early treatment European exonic expression functional Genetic genetic regulation Haplotype Hospitalization Hospitalized in vitro study interferon interferons locus mitigate molecular mechanism molecular mechanisms OAS1 Patient Protein reduced Regulation risk SARS-CoV-2 SARS-CoV-2 clearance severe COVID-19 splicing susceptibility variant with COVID-19 [DOI] 10.1038/s41588-022-01113-z PMC 바로가기 [Article Type] Article
ABO blood group and link to COVID-19: A comprehensive review of the reported associations and their possible underlying mechanismsABO 혈액형 및 COVID-19와의 연관성: 보고된 연관성 및 가능한 기본 메커니즘에 대한 포괄적인 검토Review Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABO ABO antibodies ABO blood Group system ABO blood type ABO blood types Affect antibodies Antigen association associations Blood Blood Group blood group system blood type cells COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVID-19 severity described Disease progression disease severity disease transmission Diseases explain facilitate genetic association genetic associations glycobiology glycoprotein group higher risk Host hypothese implication Infectious diseases Interaction locus lower risk management mechanism Mortality natural history outcome outcomes progression protective effect protective factor reported risk risk factor risk of infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severity Structure susceptibility the disease thromboembolic Thromboembolic event Thromboembolic events Transmission transmitted with COVID-19 [DOI] 10.1016/j.micpath.2022.105658 PMC 바로가기 [Article Type] Review
Comparative analysis of SARS-CoV-2 quasispecies in the upper and lower respiratory tract shows an ongoing evolution in the spike cleavage site상부 및 하부 호흡기에서 SARS-CoV-2 유사종의 비교 분석은 스파이크 절단 부위에서 진행 중인 진화를 보여줍니다Article Published on 2022-07-022022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Cell cleavage site Comparative analysis coronavirus deep deep sequencing Deleterious mutations evidenced Evolution explained genomic humans incidence INDEL indels intensive care intensive care unit locus Lower respiratory tract LRT Macrophage Minority variants Mutation Next-generation sequencing Non-synonymous mutation Patient phagocytosis Quasispecies quasispecy Result S gene SARS-CoV-2 selective severe acute respiratory syndrome Coronavirus specimens spike Spike protein spillover. the Spike upper and lower respiratory tract upper respiratory tract URT variant variants viral quasispecy virus was performed [DOI] 10.1016/j.virusres.2022.198786 PMC 바로가기 [Article Type] Article